Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q16820
UPID:
MEP1B_HUMAN
Alternative names:
Endopeptidase-2; Meprin B; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
Alternative UPACC:
Q16820; B7ZM35; B9EGL6; Q670J1
Background:
Meprin A subunit beta, also known as Meprin B, is a membrane metallopeptidase crucial for shedding many membrane-bound proteins. It exhibits a strong preference for acidic amino acids at the P1' position, processing substrates like FGF19, VGFA, and IL1B. This protein plays a significant role in inflammation and tissue remodeling by degrading extracellular matrix components.
Therapeutic significance:
Understanding the role of Meprin A subunit beta could open doors to potential therapeutic strategies, especially in managing inflammation and facilitating tissue repair.