Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q3SY69
UPID:
AL1L2_HUMAN
Alternative names:
Aldehyde dehydrogenase family 1 member L2
Alternative UPACC:
Q3SY69; Q3SY68; Q68D62; Q6AI55; Q8N922
Background:
Mitochondrial 10-formyltetrahydrofolate dehydrogenase, also known as Aldehyde dehydrogenase family 1 member L2, plays a crucial role in cellular metabolism. It catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide, a key reaction in the formate pathway of folate metabolism.
Therapeutic significance:
Understanding the role of Mitochondrial 10-formyltetrahydrofolate dehydrogenase could open doors to potential therapeutic strategies. Its pivotal function in folate metabolism suggests its potential impact on cellular processes and disease mechanisms.