Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q495T6
UPID:
MMEL1_HUMAN
Alternative names:
Membrane metallo-endopeptidase-like 2; NEP2(m); Neprilysin II; Neprilysin-2
Alternative UPACC:
Q495T6; B9DI79; Q495T7; Q495T8; Q5SZS6; Q96PH9
Background:
Membrane metallo-endopeptidase-like 1, also known as Neprilysin-2, plays a crucial role in sperm function and early embryonic development. It degrades a variety of small peptides, preferring those under 3 kDa with neutral bulky aliphatic or aromatic residues. Its substrate specificity mirrors that of MME, targeting the same amide bonds.
Therapeutic significance:
Understanding the role of Membrane metallo-endopeptidase-like 1 could open doors to potential therapeutic strategies. Its involvement in key reproductive processes highlights its significance in fertility treatments and embryonic health.