Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q53GD3
UPID:
CTL4_HUMAN
Alternative names:
Solute carrier family 44 member 4; Thiamine pyrophosphate transporter 1
Alternative UPACC:
Q53GD3; A2BED3; B0UXX8; B0UZY8; B4DU94; B4DWM2; E9PEK7; Q5JP84; Q5JQ93; Q658S8; Q6UX89; Q8TEW4; Q96C58; Q96K59; Q9Y332
Background:
Choline transporter-like protein 4, also known as Solute carrier family 44 member 4 and Thiamine pyrophosphate transporter 1, plays a crucial role in the choline-acetylcholine system. It is essential for the efferent innervation of hair cells in the olivocochlear bundle, maintaining the physiological function of outer hair cells and protecting them from acoustic injury. Additionally, it functions as a thiamine pyrophosphate transporter in the colon, contributing to host thiamine homeostasis.
Therapeutic significance:
The protein's involvement in Deafness, autosomal dominant, 72, a form of non-syndromic sensorineural hearing loss affecting middle frequencies, highlights its potential as a target for therapeutic intervention. Understanding the role of Choline transporter-like protein 4 could open doors to novel treatments for hearing loss and thiamine deficiency disorders.