Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q5H8A4
UPID:
PIGG_HUMAN
Alternative names:
GPI7 homolog; Phosphatidylinositol-glycan biosynthesis class G protein
Alternative UPACC:
Q5H8A4; B4DKC7; Q2TAK5; Q6UX31; Q7L5Y4; Q8N866; Q8NCC9; Q96SY9; Q9BVT7; Q9NXG5
Background:
GPI ethanolamine phosphate transferase 2, also known as GPI7 homolog and Phosphatidylinositol-glycan biosynthesis class G protein, plays a crucial role in glycosylphosphatidylinositol-anchor biosynthesis. This process is essential for attaching certain proteins to the cell membrane, facilitating cell-to-cell communication and signal transduction.
Therapeutic significance:
The protein is linked to a neurodevelopmental disorder characterized by delayed psychomotor development, hypotonia, seizures, and possible cerebellar atrophy. Understanding the role of GPI ethanolamine phosphate transferase 2 could open doors to potential therapeutic strategies for this disorder.