Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q5JRX3
UPID:
PREP_HUMAN
Alternative names:
Pitrilysin metalloproteinase 1
Alternative UPACC:
Q5JRX3; B3KMJ6; B4E0J8; C9JSL2; E7ES23; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8
Background:
Presequence protease, mitochondrial, also known as Pitrilysin metalloproteinase 1, is a crucial enzyme in the mitochondrial matrix. It specializes in peptide cleavage and degradation, targeting peptides ranging from 5 to 65 residues. This protease exhibits a preference for cleaving after small polar residues and before basic residues. It plays a pivotal role in degrading the transit peptides of mitochondrial proteins and other unstructured peptides, including the amyloid-beta protein 40, a key player in neurodegenerative diseases.
Therapeutic significance:
Given its ability to degrade amyloid-beta protein 40, Presequence protease, mitochondrial, holds promise in the treatment of neurodegenerative diseases such as Alzheimer's. Understanding the role of this protein could open doors to potential therapeutic strategies, especially in conditions where amyloid-beta accumulation is a hallmark.