Focused On-demand Library for Spindlin-3

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.

Our top-notch dedicated system is used to design specialised libraries.

Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q5JUX0

UPID:

SPIN3_HUMAN

Alternative names:

Spindlin-like protein 3

Alternative UPACC:

Q5JUX0; B2RUW3; B7Z8W2; Q8N5D9

Background:

Spindlin-3, also known as Spindlin-like protein 3, is recognized for its H3K4me3-binding activity. This protein plays a crucial role in the regulation of gene expression by interacting with histone modifications, a key aspect of epigenetic control. The ability of Spindlin-3 to recognize and bind specific histone marks positions it as a significant player in the orchestration of chromatin dynamics and cellular function.

Therapeutic significance:

Understanding the role of Spindlin-3 could open doors to potential therapeutic strategies. Its involvement in epigenetic regulation suggests that targeting Spindlin-3 could offer new avenues for the treatment of diseases where gene expression is dysregulated. As research progresses, the therapeutic potential of Spindlin-3 continues to be an area of significant interest.