Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q5QNW6
UPID:
H2B2F_HUMAN
Alternative names:
H2B-clustered histone 18
Alternative UPACC:
Q5QNW6; A8K0U9; B4DLA9
Background:
Histone H2B type 2-F, also known as H2B-clustered histone 18, is a core component of the nucleosome. Nucleosomes are critical for DNA compaction into chromatin, influencing DNA's accessibility for transcription, repair, replication, and stability. The regulation of DNA accessibility is mediated through histone modifications and nucleosome remodeling.
Therapeutic significance:
Understanding the role of Histone H2B type 2-F could open doors to potential therapeutic strategies.