Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q5SXM8
UPID:
DNLZ_HUMAN
Alternative names:
Hsp70-escort protein 1; mtHsp70-escort protein
Alternative UPACC:
Q5SXM8; B2RUX5; B9EJE1
Background:
The DNL-type zinc finger protein, also known as Hsp70-escort protein 1 or mtHsp70-escort protein, plays a crucial role in cellular processes. It is believed to act as a co-chaperone for HSPA9/mortalin, a protein that tends to self-aggregate without proper support. This interaction highlights the protein's importance in maintaining cellular homeostasis and protein quality control.
Therapeutic significance:
Understanding the role of DNL-type zinc finger protein could open doors to potential therapeutic strategies. Its involvement in protein folding and stabilization processes makes it a candidate for targeting in diseases where protein misfolding is a key pathology.