Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q5T6F0
UPID:
DCA12_HUMAN
Alternative names:
Centrosome-related protein TCC52; Testis cancer centrosome-related protein; WD repeat-containing protein 40A
Alternative UPACC:
Q5T6F0; A8KA70; D3DRL6; Q5T6E9; Q5T6F1; Q6P3V0; Q7L4F8; Q96PZ5; Q9NXA9; Q9UFJ1
Background:
DDB1- and CUL4-associated factor 12 (DCAF12) serves as a substrate-recognition component of the DCX E3 ubiquitin-protein ligase complex, pivotal in the DesCEND pathway. It targets proteins with specific C-terminal motifs for ubiquitination and degradation, including those with diglutamate or glutamate-leucine degrons. This process is crucial for cellular functions such as starvation-induced autophagy.
Therapeutic significance:
Understanding the role of DDB1- and CUL4-associated factor 12 could open doors to potential therapeutic strategies.