Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q5TD94
UPID:
RSH4A_HUMAN
Alternative names:
Radial spoke head-like protein 3
Alternative UPACC:
Q5TD94; B4DSI1; Q3KP24; Q5TD95
Background:
Radial spoke head protein 4 homolog A, also known as Radial spoke head-like protein 3, plays a crucial role in ciliary motility by being a component of the axonemal radial spoke head. Its involvement is essential for the assembly of triplet radial spokes head in motile cilia, highlighting its significance in cellular movement and fluid flow across cell surfaces.
Therapeutic significance:
The protein is directly linked to Primary ciliary dyskinesia, 11, a disorder marked by motile cilia abnormalities leading to severe respiratory infections and reduced fertility. Understanding the role of Radial spoke head protein 4 homolog A could open doors to potential therapeutic strategies for treating this condition.