Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q676U5
UPID:
A16L1_HUMAN
Alternative names:
APG16-like 1
Alternative UPACC:
Q676U5; A3EXK9; A3EXL0; B6ZDH0; Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619
Background:
Autophagy-related protein 16-1, also known as APG16-like 1, is pivotal in autophagy, facilitating the lipidation of ATG8 family proteins. This process is crucial for the formation and elongation of the autophagosomal membrane, impacting both canonical and non-canonical autophagy pathways.
Therapeutic significance:
Given its role in autophagy, a process integral to cellular homeostasis and defense, Autophagy-related protein 16-1 is linked to Inflammatory bowel disease 10. Understanding its function could lead to novel therapeutic strategies for this and potentially other autophagy-related diseases.