Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q68D06
UPID:
SLN13_HUMAN
Alternative names:
Schlafen-13
Alternative UPACC:
Q68D06; E1P645; Q658M1; Q6ZS51; Q96A81
Background:
Schlafen family member 13, also known as Schlafen-13, is a protein encoded by the gene with the accession number Q68D06. It functions as an endoribonuclease, specifically cleaving tRNAs and rRNAs. Schlafen-13 distinguishes itself by cleaving tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem, excluding tRNA(Sec). Its unique mechanism of action includes the ability to restrict HIV-1 virus replication, a process that hinges on its endoribonuclease activity.
Therapeutic significance:
Understanding the role of Schlafen family member 13 could open doors to potential therapeutic strategies. Its ability to inhibit HIV-1 replication, dependent on its endoribonuclease activity, highlights its potential as a target for antiviral therapy development.