Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q68E01
UPID:
INT3_HUMAN
Alternative names:
SOSS complex subunit A; Sensor of single-strand DNA complex subunit A
Alternative UPACC:
Q68E01; A8K1W0; B4DQC8; B4E3U9; D3DV57; Q4G0E5; Q5VUQ5; Q5VUQ6; Q5VUR0; Q5VUR1; Q68DJ1; Q69YR5; Q6AI57; Q6DKG7; Q6MZQ4; Q6MZZ9; Q8NC46; Q8TB23; Q9H6S9
Background:
Integrator complex subunit 3 (Integrator complex subunit 3), also known as SOSS complex subunit A, plays a crucial role in the transcription and processing of small nuclear RNAs (snRNAs) U1 and U2. It is a part of the Integrator complex, associated with RNA polymerase II, and the SOSS complex, which promotes DNA repair and genomic stability.
Therapeutic significance:
Understanding the role of Integrator complex subunit 3 could open doors to potential therapeutic strategies.