Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6FIF0
UPID:
ZFAN6_HUMAN
Alternative names:
Associated with PRK1 protein; Zinc finger A20 domain-containing protein 3
Alternative UPACC:
Q6FIF0; D3DW92; D3DW94; O95792; Q9BQF7; Q9GZY3
Background:
AN1-type zinc finger protein 6, also known as Associated with PRK1 protein and Zinc finger A20 domain-containing protein 3, plays a crucial role in cellular processes. It regulates TNF-alpha induced NF-kappa-B activation and apoptosis, modulates 'Lys-48'-linked polyubiquitination status of TRAF2, and is involved in peroxisomal protein import via interaction with PEX5 and PEX6. Its activity is essential for maintaining cellular homeostasis and responding to stress signals.
Therapeutic significance:
Understanding the role of AN1-type zinc finger protein 6 could open doors to potential therapeutic strategies. Its involvement in NF-kappa-B activation, apoptosis, and protein import into peroxisomes highlights its importance in cellular regulation and stress response, making it a potential target for drug discovery efforts aimed at treating diseases linked to these pathways.