Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6P9G0
UPID:
CB5D1_HUMAN
Alternative names:
-
Alternative UPACC:
Q6P9G0; D3DTQ8; Q96DM7
Background:
Cytochrome b5 domain-containing protein 1, identified by the accession number Q6P9G0, plays a crucial role in ciliary function. It binds heme under oxidizing conditions, essential for the coordinated beating of multiple cilia. This suggests its involvement in a redox signaling pathway, pivotal for cellular and physiological processes.
Therapeutic significance:
Understanding the role of Cytochrome b5 domain-containing protein 1 could open doors to potential therapeutic strategies. Its involvement in ciliary function and redox signaling pathways presents a unique opportunity for targeting diseases with impaired ciliary movement or redox imbalances.