Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q6PIF6
UPID:
MYO7B_HUMAN
Alternative names:
-
Alternative UPACC:
Q6PIF6; Q14786; Q8TEE1
Background:
Unconventional myosin-VIIb, encoded by the gene with accession number Q6PIF6, is a unique actin-based motor molecule characterized by its ATPase activity and a highly divergent tail presumed to bind to membranous compartments. This protein plays a crucial role in epithelial brush border differentiation by controlling microvilli organization and length, likely linking the intermicrovillar adhesion complex to the actin core bundle of microvilli.
Therapeutic significance:
Understanding the role of Unconventional myosin-VIIb could open doors to potential therapeutic strategies.