Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q6Q759
UPID:
SPG17_HUMAN
Alternative names:
Projection protein PF6 homolog
Alternative UPACC:
Q6Q759; Q8NAZ1; Q9NT21
Background:
Sperm-associated antigen 17, also known as Projection protein PF6 homolog, is pivotal in motile cilia function and structure. It is integral to spermatogenesis, influencing sperm motility and fertility by facilitating proper sperm head and flagellum formation. Its role extends to the development of the sperm flagellum and the assembly of the respiratory motile cilia central pair apparatus.
Therapeutic significance:
Spermatogenic failure 55, an autosomal recessive male infertility disorder characterized by asthenozoospermia, is linked to this protein. Understanding the role of Sperm-associated antigen 17 could unveil new therapeutic strategies for treating male infertility.