Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q6QEF8
UPID:
CORO6_HUMAN
Alternative names:
Coronin-like protein E
Alternative UPACC:
Q6QEF8; B3KU26; Q71MF3; Q8WYH7; Q96K02
Background:
Coronin-6, known alternatively as Coronin-like protein E, is a protein encoded by the gene with the accession number Q6QEF8. Its specific functions within cellular processes remain to be fully elucidated, yet its naming suggests a potential involvement in the coronin protein family, which plays roles in modulating cytoskeletal dynamics.
Therapeutic significance:
Understanding the role of Coronin-6 could open doors to potential therapeutic strategies. Its association with the coronin protein family hints at its importance in cellular functions, which could be pivotal in disease mechanisms and treatment modalities.