Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6UXH0
UPID:
ANGL8_HUMAN
Alternative names:
Betatrophin; Lipasin; Refeeding-induced fat and liver protein
Alternative UPACC:
Q6UXH0; Q9NQZ1
Background:
Angiopoietin-like protein 8, known as Betatrophin, Lipasin, and Refeeding-induced fat and liver protein, plays a crucial role in lipid metabolism. It regulates serum triglyceride levels and directs fatty acids to adipose tissue for storage, marking its significance in the metabolic transition between fasting and refeeding.
Therapeutic significance:
Given its involvement in Type 1 and Type 2 diabetes mellitus, understanding the role of Angiopoietin-like protein 8 could open doors to potential therapeutic strategies. Its association with serum protein levels in diabetes patients highlights its potential as a target for therapeutic intervention.