Focused On-demand Library for Cytochrome P450 26C1

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Several key aspects differentiate our library:

  • Receptor.AI compiles an all-encompassing dataset on the target protein, including historical experiments, literature data, known ligands, and structural insights, maximising the chances of prioritising the most pertinent compounds.
  • The platform employs state-of-the-art molecular simulations to identify potential binding sites, ensuring the focused library is primed for discovering allosteric inhibitors and binders of concealed pockets.
  • Over 50 customisable AI models, thoroughly evaluated in various drug discovery endeavours and research projects, make Receptor.AI both efficient and accurate. This technology is integral to the development of our focused libraries.
  • In addition to generating focused libraries, Receptor.AI offers a full range of services and solutions for every step of preclinical drug discovery, with a pricing model based on success, thereby reducing risk and promoting joint project success.







Alternative names:


Alternative UPACC:

Q6V0L0; Q5VXH6


Cytochrome P450 26C1 plays a pivotal role in the metabolism of retinoates, the active metabolites of vitamin A, crucial for signaling in animals. It specifically catalyzes the oxidation of all-trans-retinoic acid (atRA), the biologically active isomer of vitamin A, along with other isomers like 9-cis-RA, contributing to the regulation of atRA homeostasis and signaling. This enzyme's unique ability to metabolize retinoates with high efficiency underscores its significance in maintaining proper cellular function.

Therapeutic significance:

Given its involvement in the metabolism of retinoates, critical for cellular signaling and homeostasis, Cytochrome P450 26C1's dysfunction is linked to Focal facial dermal dysplasia 4, characterized by preauricular skin lesions. Understanding the role of Cytochrome P450 26C1 could open doors to potential therapeutic strategies for managing this condition and possibly other retinoic acid-related disorders.

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