Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6X4W1
UPID:
NSMF_HUMAN
Alternative names:
Nasal embryonic luteinizing hormone-releasing hormone factor
Alternative UPACC:
Q6X4W1; Q2TB96; Q6X4V7; Q6X4V8; Q6X4V9; Q8N2M2; Q96SY1; Q9NPM4; Q9NPP3; Q9NPS3
Background:
The NMDA receptor synaptonuclear signaling and neuronal migration factor, also known as Nasal embryonic luteinizing hormone-releasing hormone factor, plays a pivotal role in neural development. It is essential for the signaling of NMDA-sensitive glutamate receptors to the nucleus, influencing the long-lasting changes in dendrites and spine synapse processes. This protein is crucial for the outgrowth of olfactory axons and the migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
Therapeutic significance:
Given its involvement in Hypogonadotropic hypogonadism 9 with or without anosmia, a disorder linked to absent or incomplete sexual maturation and low levels of circulating gonadotropins and testosterone, understanding the role of this protein could lead to novel therapeutic strategies for treating this condition and potentially related reproductive and sensory disorders.