Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6ZMI3
UPID:
GLDN_HUMAN
Alternative names:
-
Alternative UPACC:
Q6ZMI3; Q6UXZ7; Q7Z359
Background:
Gliomedin, a pivotal protein, facilitates the formation and maintenance of nodes of Ranvier, essential for rapid signal transmission in myelinated axons. It acts as a ligand for NRCAM and NFASC, mediating Schwann cell and axon interactions, crucial for the saltatory conduction of action potentials. Its role extends to the clustering of sodium channels, vital for neural communication.
Therapeutic significance:
Gliomedin's association with Lethal congenital contracture syndrome 11, due to gene variants, underscores its clinical importance. Understanding Gliomedin's functions could pave the way for innovative treatments for neuromuscular disorders, highlighting its therapeutic potential.