Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q71DI3
UPID:
H32_HUMAN
Alternative names:
H3-clustered histone 13; H3-clustered histone 14; H3-clustered histone 15; Histone H3/m; Histone H3/o
Alternative UPACC:
Q71DI3; A2BDF6; A6NFS4; Q6B053
Background:
Histone H3.2, identified by the accession number Q71DI3, is a core component of the nucleosome, playing a pivotal role in DNA compaction into chromatin. This process is crucial for transcription regulation, DNA repair, replication, and chromosomal stability. Histone H3.2 is subject to a variety of post-translational modifications, collectively known as the histone code, which regulate DNA accessibility and nucleosome remodeling.
Therapeutic significance:
Understanding the role of Histone H3.2 could open doors to potential therapeutic strategies.