Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q7Z3S7
UPID:
CA2D4_HUMAN
Alternative names:
Voltage-gated calcium channel subunit alpha-2/delta-4
Alternative UPACC:
Q7Z3S7; Q7Z3S8; Q86XZ5; Q8IZS9
Background:
The Voltage-dependent calcium channel subunit alpha-2/delta-4 plays a pivotal role in regulating calcium current density and the kinetics of calcium channel activation and inactivation. This protein, also known as Voltage-gated calcium channel subunit alpha-2/delta-4, is integral to the proper functioning of voltage-dependent calcium channels, which are crucial for the transmission of electrical signals in the nervous system and other physiological processes.
Therapeutic significance:
Linked to Retinal cone dystrophy 4, a condition marked by a gradual decline in visual acuity, the alpha-2/delta-4 subunit's dysfunction underscores its potential as a target for therapeutic intervention. Understanding the role of Voltage-dependent calcium channel subunit alpha-2/delta-4 could open doors to potential therapeutic strategies.