Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q7Z4G1
UPID:
COMD6_HUMAN
Alternative names:
-
Alternative UPACC:
Q7Z4G1; A6NF28; B7ZLN0; Q5TBK4
Background:
COMM domain-containing protein 6 plays a crucial role in cellular processes by modulating the activity of cullin-RING E3 ubiquitin ligase complexes, as highlighted in PubMed:21778237. It serves as a key regulator in down-regulating the activation of NF-kappa-B and inhibits TNF-induced NFKB1 activation, showcasing its significant impact on inflammatory pathways.
Therapeutic significance:
Understanding the role of COMM domain-containing protein 6 could open doors to potential therapeutic strategies. Its involvement in regulating key inflammatory pathways positions it as a promising target for drug discovery efforts aimed at treating diseases characterized by excessive inflammation.