Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q7Z5K2
UPID:
WAPL_HUMAN
Alternative names:
Friend of EBNA2 protein; WAPL cohesin release factor
Alternative UPACC:
Q7Z5K2; A7E2B5; Q5VSK5; Q8IX10; Q92549
Background:
The Wings apart-like protein homolog, also known as Friend of EBNA2 protein and WAPL cohesin release factor, plays a pivotal role in cell division. It is a key regulator of sister chromatid cohesion in mitosis, ensuring accurate chromosome partitioning by negatively regulating cohesin association with chromatin. This protein is crucial during both interphase for sister chromatid cohesion and the early stages of mitosis for sister-chromatid resolution. Its function of coupling DNA replication to sister chromatid cohesion underscores its importance in both meiotic and mitotic cells, as well as in DNA repair processes.
Therapeutic significance:
Understanding the role of Wings apart-like protein homolog could open doors to potential therapeutic strategies.