Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q86SS6
UPID:
SYT9_HUMAN
Alternative names:
Synaptotagmin IX
Alternative UPACC:
Q86SS6
Background:
Synaptotagmin-9, alternatively known as Synaptotagmin IX, plays a crucial role in the Ca(2+)-dependent exocytosis of secretory vesicles. This process is vital for the proper functioning of cellular communication and neurotransmitter release, facilitated through the binding of calcium ions and phospholipids to the C2 domain of Synaptotagmin-9.
Therapeutic significance:
Understanding the role of Synaptotagmin-9 could open doors to potential therapeutic strategies. Its involvement in vesicular trafficking and exocytosis positions it as a key player in neuronal activity and synaptic function, suggesting its potential as a target in neurological disorder treatments.