Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q86T26
UPID:
TM11B_HUMAN
Alternative names:
Airway trypsin-like protease 5
Alternative UPACC:
Q86T26; A8K4D9
Background:
Transmembrane protease serine 11B, also known as Airway trypsin-like protease 5, is a serine protease that plays a crucial role in various biological processes. Its unique structure and function make it an essential component in the proteolytic network, contributing to protein regulation and signaling pathways.
Therapeutic significance:
Understanding the role of Transmembrane protease serine 11B could open doors to potential therapeutic strategies. Its involvement in critical biological mechanisms positions it as a key target for drug discovery, aiming to modulate its activity for therapeutic benefits.