Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q86UD3
UPID:
MARH3_HUMAN
Alternative names:
Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; RING finger protein 173; RING-type E3 ubiquitin transferase MARCHF3
Alternative UPACC:
Q86UD3; A8K264; B9EJE7
Background:
E3 ubiquitin-protein ligase MARCHF3, also known as Membrane-associated RING finger protein 3, plays a crucial role in endosomal trafficking. This protein, identified by the unique identifier Q86UD3, functions by accepting ubiquitin from an E2 ubiquitin-conjugating enzyme and transferring it directly to targeted substrates. Its alternative names include Membrane-associated RING-CH protein III, RING finger protein 173, and RING-type E3 ubiquitin transferase MARCHF3.
Therapeutic significance:
Understanding the role of E3 ubiquitin-protein ligase MARCHF3 could open doors to potential therapeutic strategies.