Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q86UV7
UPID:
TRI73_HUMAN
Alternative names:
Tripartite motif-containing protein 50B
Alternative UPACC:
Q86UV7; Q8N0S3
Background:
Tripartite motif-containing protein 73, also known as Tripartite motif-containing protein 50B, plays a crucial role in cellular processes. Its unique structure, characterized by the presence of a tripartite motif, suggests a multifunctional capability in regulating various biological pathways. The protein's involvement in cellular mechanisms is underscored by its alternative name, highlighting its significance in the tripartite motif family.
Therapeutic significance:
Understanding the role of Tripartite motif-containing protein 73 could open doors to potential therapeutic strategies. Its pivotal role in cellular processes makes it a prime candidate for further research, aiming to uncover novel therapeutic targets. The exploration of its functions and mechanisms may lead to breakthroughs in treating diseases.