AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for Tripartite motif-containing protein 73

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

We use our state-of-the-art dedicated workflow for designing focused libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Our library is unique due to several crucial aspects:

  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.

partner

Reaxense

upacc

Q86UV7

UPID:

TRI73_HUMAN

Alternative names:

Tripartite motif-containing protein 50B

Alternative UPACC:

Q86UV7; Q8N0S3

Background:

Tripartite motif-containing protein 73, also known as Tripartite motif-containing protein 50B, plays a crucial role in cellular processes. Its unique structure, characterized by the presence of a tripartite motif, suggests a multifunctional capability in regulating various biological pathways. The protein's involvement in cellular mechanisms is underscored by its alternative name, highlighting its significance in the tripartite motif family.

Therapeutic significance:

Understanding the role of Tripartite motif-containing protein 73 could open doors to potential therapeutic strategies. Its pivotal role in cellular processes makes it a prime candidate for further research, aiming to uncover novel therapeutic targets. The exploration of its functions and mechanisms may lead to breakthroughs in treating diseases.

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