Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q86VE3
UPID:
SATL1_HUMAN
Alternative names:
-
Alternative UPACC:
Q86VE3; A0A2R8Y5C1; A0AVK7; E9PB72; Q5H8V9
Background:
Spermidine/spermine N(1)-acetyltransferase-like protein 1, encoded by the gene with accession number Q86VE3, plays a crucial role in the polyamine metabolic process. Polyamines are vital for cell growth and function, indicating this protein's importance in cellular physiology.
Therapeutic significance:
Understanding the role of Spermidine/spermine N(1)-acetyltransferase-like protein 1 could open doors to potential therapeutic strategies. Its involvement in polyamine metabolism suggests a possible link to cellular growth pathways, offering a promising avenue for research into cancer and other growth-related disorders.