AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for COMM domain-containing protein 7

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our top-notch dedicated system is used to design specialised libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q86VX2

UPID:

COMD7_HUMAN

Alternative names:

-

Alternative UPACC:

Q86VX2; A2BHJ2; B3KTZ2; Q5JYB0; Q96SI7; Q9BW53

Background:

COMM domain-containing protein 7 plays a crucial role in cellular processes by modulating the activity of cullin-RING E3 ubiquitin ligase complexes, as evidenced by research findings. Additionally, it associates with the NF-kappa-B complex, significantly suppressing its transcriptional activity. This protein's intricate involvement in cellular regulation underscores its importance in maintaining cellular homeostasis.

Therapeutic significance:

Understanding the role of COMM domain-containing protein 7 could open doors to potential therapeutic strategies. Its ability to interact with key cellular complexes suggests that targeting this protein could influence cellular processes related to disease pathogenesis.

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