Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q86W50
UPID:
MET16_HUMAN
Alternative names:
Methyltransferase 10 domain-containing protein; Methyltransferase-like protein 16; N6-adenosine-methyltransferase METTL16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Alternative UPACC:
Q86W50; D3DTI8; Q86TE5; Q96T16; Q9BVG7
Background:
RNA N6-adenosine-methyltransferase METTL16 is a pivotal enzyme in RNA processing, specifically targeting adenosine residues for methylation. This protein plays a crucial role in S-adenosyl-L-methionine homeostasis, influencing the expression of MAT2A transcripts. METTL16's unique ability to methylate a select subset of mRNAs and U6 snRNAs, contingent upon specific sequence and structural prerequisites, underscores its specificity and importance in RNA metabolism.
Therapeutic significance:
Understanding the role of RNA N6-adenosine-methyltransferase METTL16 could open doors to potential therapeutic strategies.