Focused On-demand Library for Lon protease homolog 2, peroxisomal

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.

Our library is unique due to several crucial aspects:

  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.







Alternative names:

Lon protease-like protein 2; Peroxisomal Lon protease

Alternative UPACC:

Q86WA8; B7ZKL7; Q0D2H6; Q8N3B9; Q8NCE9; Q96K43


Lon protease homolog 2, peroxisomal, also known as Lon protease-like protein 2, plays a crucial role in cellular homeostasis. It acts as an ATP-dependent serine protease, targeting misfolded and unassembled polypeptides within the peroxisomal matrix for selective degradation. This protein is essential for processing proteins containing the type 2 peroxisome targeting signal (PTS2) and supports the import of matrix proteins into peroxisomes. Its activity is pivotal for the maintenance of peroxisomal function and indirectly influences fatty acid beta-oxidation.

Therapeutic significance:

Understanding the role of Lon protease homolog 2, peroxisomal could open doors to potential therapeutic strategies.

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