Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q86XE5
UPID:
HOGA1_HUMAN
Alternative names:
Dihydrodipicolinate synthase-like; Probable 2-keto-4-hydroxyglutarate aldolase; Protein 569272
Alternative UPACC:
Q86XE5; A8K075; Q5T680; Q5T684; Q711P0; Q8N9F2; Q96EV5
Background:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial, known alternatively as Dihydrodipicolinate synthase-like, Probable 2-keto-4-hydroxyglutarate aldolase, and Protein 569272, plays a pivotal role in the metabolic pathway of hydroxyproline. This enzyme catalyzes the final step, showcasing its critical function in metabolism.
Therapeutic significance:
Linked to Hyperoxaluria primary 3, a disorder marked by increased urinary oxalate excretion and mild glycolic aciduria, this protein's mutation underscores its clinical importance. Understanding the role of 4-hydroxy-2-oxoglutarate aldolase could open doors to potential therapeutic strategies for managing and treating this condition.