Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q86XI2
UPID:
CNDG2_HUMAN
Alternative names:
Chromosome-associated protein G2; Leucine zipper protein 5; Non-SMC condensin II complex subunit G2
Alternative UPACC:
Q86XI2; A4D228; Q7Z3J9; Q8WUG8; Q9BRX6; Q9H8S2; Q9H9K6
Background:
Condensin-2 complex subunit G2, also known as Chromosome-associated protein G2, Leucine zipper protein 5, and Non-SMC condensin II complex subunit G2, plays a pivotal role in mitotic chromosome architecture. It acts as a regulatory subunit of the condensin-2 complex, crucial for establishing the physical rigidity of the chromatid axis during cell division.
Therapeutic significance:
Linked to Khan-Khan-Katsanis syndrome, a neurodevelopmental disorder with wide-ranging congenital anomalies, the study of Condensin-2 complex subunit G2 offers a promising avenue for therapeutic intervention. Understanding its role could open doors to potential therapeutic strategies targeting the underlying genetic variants.