Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8IUZ5
UPID:
AT2L2_HUMAN
Alternative names:
Alanine--glyoxylate aminotransferase 2-like 2
Alternative UPACC:
Q8IUZ5; A8K7P6; B3KN36; D3DWP9; Q8WYS6; Q96HW8
Background:
The 5-phosphohydroxy-L-lysine phospho-lyase, also known as Alanine--glyoxylate aminotransferase 2-like 2, plays a crucial role in amino acid metabolism. It catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine into ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. This enzymatic activity is essential for the proper processing and elimination of specific amino acids in the body.
Therapeutic significance:
Linked to Phosphohydroxylysinuria, a condition marked by elevated phosphohydroxylysine in the urine, this protein's gene variants underline the disease's genetic basis. Understanding the role of 5-phosphohydroxy-L-lysine phospho-lyase could open doors to potential therapeutic strategies, offering insights into targeted treatments for metabolic disorders.