Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8IV45
UPID:
UN5CL_HUMAN
Alternative names:
Protein unc-5 homolog C-like; ZU5 and death domain-containing protein
Alternative UPACC:
Q8IV45; Q5TGU1
Background:
The UNC5C-like protein, also known as Protein unc-5 homolog C-like and ZU5 and death domain-containing protein, plays a crucial role in cellular processes by inhibiting NF-kappa-B-dependent transcription. This inhibition is achieved through impairing NF-kappa-B's ability to bind to its targets, showcasing the protein's significant regulatory function in the cell.
Therapeutic significance:
Understanding the role of UNC5C-like protein could open doors to potential therapeutic strategies. Its pivotal function in regulating NF-kappa-B-dependent transcription suggests that it may hold the key to controlling processes involved in inflammation and immune responses, offering a promising avenue for drug discovery.