Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8IVL6
UPID:
P3H3_HUMAN
Alternative names:
Leprecan-like protein 2; Protein B
Alternative UPACC:
Q8IVL6; Q13512; Q15740; Q66K32; Q6NX61; Q7L2T1
Background:
Prolyl 3-hydroxylase 3, also known as Leprecan-like protein 2 or Protein B, plays a crucial role in collagen synthesis. It is part of a complex including PLOD1, P3H3, and P3H4, essential for the hydroxylation of lysine residues in collagen alpha chains. This process is vital for the normal assembly and cross-linking of collagen fibrils, impacting skin, bone, tendon, aorta, and cornea health.
Therapeutic significance:
Understanding the role of Prolyl 3-hydroxylase 3 could open doors to potential therapeutic strategies. Its pivotal function in collagen synthesis and assembly suggests that targeting this protein could lead to advancements in treating disorders related to collagen malformation and degradation.