Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8IW19
UPID:
APLF_HUMAN
Alternative names:
Apurinic-apyrimidinic endonuclease APLF; PNK and APTX-like FHA domain-containing protein; XRCC1-interacting protein 1
Alternative UPACC:
Q8IW19; A8K476; Q53P47; Q53PB9; Q53QU0
Background:
Aprataxin and PNK-like factor (APLF) plays a crucial role in DNA repair, acting as a histone chaperone involved in both single-strand and double-strand DNA break repair. It is recruited to sites of DNA damage, where it facilitates histone eviction and promotes the recruitment of histone variant MACROH2A1. APLF also exhibits nuclease activity, including apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities, and is involved in non-homologous end-joining (NHEJ) DNA repair pathways.
Therapeutic significance:
Understanding the role of Aprataxin and PNK-like factor could open doors to potential therapeutic strategies.