Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8IW40
UPID:
CC103_HUMAN
Alternative names:
-
Alternative UPACC:
Q8IW40; A8K145; B8ZZU0
Background:
Coiled-coil domain-containing protein 103 plays a pivotal role in cilia motility, essential for the proper functioning of motile cilia. This protein acts as a dynein-attachment factor, facilitating the movement of cilia, which are critical for various physiological processes including respiratory function and reproductive success.
Therapeutic significance:
Mutations in this protein lead to Primary Ciliary Dyskinesia, a disorder marked by respiratory infections, reduced fertility, and sometimes situs inversus, known as Kartagener syndrome when combined. Understanding the role of Coiled-coil domain-containing protein 103 could open doors to potential therapeutic strategies for these conditions.