Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8IWS0
UPID:
PHF6_HUMAN
Alternative names:
PHD-like zinc finger protein
Alternative UPACC:
Q8IWS0; A8K230; B4E0G4; D3DTG3; E9PC97; Q5JRC7; Q5JRC8; Q96JK3; Q9BRU0
Background:
PHD finger protein 6, also known as PHD-like zinc finger protein, plays a pivotal role in cellular processes by associating with ribosomal RNA promoters to suppress ribosomal RNA transcription. This regulatory function is crucial for maintaining cellular homeostasis and ensuring proper protein synthesis rates.
Therapeutic significance:
Given its involvement in Boerjeson-Forssman-Lehmann syndrome, a disorder marked by intellectual disability and metabolic abnormalities, PHD finger protein 6 presents a promising target for therapeutic intervention. Understanding the role of PHD finger protein 6 could open doors to potential therapeutic strategies aimed at mitigating the symptoms of this syndrome.