Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8IXI2
UPID:
MIRO1_HUMAN
Alternative names:
Rac-GTP-binding protein-like protein; Ras homolog gene family member T1
Alternative UPACC:
Q8IXI2; A4FVB6; A6NFV0; B4DG48; J9JIH9; Q6NUR3; Q6P9F8; Q6PJG1; Q6YMW8; Q86UB0; Q8IW28; Q8IXJ7; Q9H067; Q9H9N8; Q9NUZ2
Background:
Mitochondrial Rho GTPase 1, also known as Rac-GTP-binding protein-like protein and Ras homolog gene family member T1, plays a crucial role in mitochondrial trafficking. It is primarily involved in the control of anterograde transport of mitochondria and their subcellular distribution. Additionally, it promotes mitochondrial fission during high calcium conditions, highlighting its importance in cellular energy dynamics and signaling.
Therapeutic significance:
Understanding the role of Mitochondrial Rho GTPase 1 could open doors to potential therapeutic strategies. Its involvement in mitochondrial dynamics suggests a pivotal role in cellular health and disease, offering a promising target for drug discovery efforts aimed at modulating mitochondrial function.