Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8IYS5
UPID:
OSCAR_HUMAN
Alternative names:
Polymeric immunoglobulin receptor 3
Alternative UPACC:
Q8IYS5; B7WNS2; Q5GRG5; Q8N763; Q8NHL4; Q8WXQ0; Q8WXQ1; Q8WXQ2
Background:
The Osteoclast-associated immunoglobulin-like receptor, also known as Polymeric immunoglobulin receptor 3, plays a pivotal role in bone health. It is a key regulator of osteoclastogenesis, which is essential for osteoclast differentiation. This differentiation process is crucial for maintaining the balance between bone formation and bone resorption.
Therapeutic significance:
Understanding the role of Osteoclast-associated immunoglobulin-like receptor could open doors to potential therapeutic strategies. Its critical function in osteoclastogenesis highlights its potential as a target for treating diseases related to bone density and strength.