Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8IYT4
UPID:
KATL2_HUMAN
Alternative names:
p60 katanin-like 2
Alternative UPACC:
Q8IYT4
Background:
Katanin p60 ATPase-containing subunit A-like 2, also known as p60 katanin-like 2, plays a crucial role in cellular dynamics by severing microtubules in an ATP-dependent manner. This action facilitates the rapid reorganization of microtubule arrays, essential for cell division, intracellular transport, and cellular morphology.
Therapeutic significance:
Understanding the role of Katanin p60 ATPase-containing subunit A-like 2 could open doors to potential therapeutic strategies. Its pivotal function in microtubule severing positions it as a key target for modulating cellular processes involved in various diseases.