Focused On-demand Library for Sodium leak channel NALCN

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.

Our library is unique due to several crucial aspects:

  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.







Alternative names:

CanIon; Sodium leak channel non-selective protein; Voltage gated channel-like protein 1

Alternative UPACC:

Q8IZF0; Q6P2S6; Q6ZMI7; Q8IZZ1; Q8TAH1


The Sodium leak channel NALCN, also known as CanIon, Sodium leak channel non-selective protein, and Voltage gated channel-like protein 1, plays a pivotal role in neuronal excitability. It is the voltage-sensing, pore-forming subunit of the NALCN channel complex, which is essential for the resting Na(+) permeability. This channel complex, including NALCN, NALF1, UNC79, and UNC80, is constitutively active, conducting monovalent cations but blocked by extracellular divalent cations. NALCN's functions extend to regulating respiratory rhythm, systemic osmoregulation, and intestinal pace-making activity.

Therapeutic significance:

NALCN's involvement in diseases such as Hypotonia, infantile, with psychomotor retardation and characteristic facies 1, and Congenital contractures of the limbs and face, hypotonia, and developmental delay, underscores its therapeutic potential. Understanding the role of Sodium leak channel NALCN could open doors to potential therapeutic strategies for these neurodegenerative and developmental disorders.

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