Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8N0S6
UPID:
CENPL_HUMAN
Alternative names:
Interphase centromere complex protein 33
Alternative UPACC:
Q8N0S6; Q5TEL5; Q96ND4
Background:
Centromere protein L, also known as Interphase centromere complex protein 33, plays a crucial role in cell division. It is a component of the CENPA-CAD complex, essential for the assembly of kinetore proteins, mitotic progression, and chromosome segregation. This protein facilitates the incorporation of newly synthesized CENPA into centromeres, highlighting its importance in maintaining genomic stability.
Therapeutic significance:
Understanding the role of Centromere protein L could open doors to potential therapeutic strategies. Its pivotal function in cell division and chromosome segregation positions it as a key target for developing treatments aimed at controlling cell proliferation in various diseases.