Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8N5K1
UPID:
CISD2_HUMAN
Alternative names:
Endoplasmic reticulum intermembrane small protein; MitoNEET-related 1 protein; Nutrient-deprivation autophagy factor-1
Alternative UPACC:
Q8N5K1; Q7Z3D5
Background:
CDGSH iron-sulfur domain-containing protein 2, also known as Endoplasmic reticulum intermembrane small protein, MitoNEET-related 1 protein, and Nutrient-deprivation autophagy factor-1, plays a pivotal role in cellular autophagy regulation. It interacts with BCL2 and BECN1 to modulate endoplasmic reticulum Ca(2+) levels during autophagy and is crucial for BIK-initiated autophagy, influencing life span control.
Therapeutic significance:
Given its involvement in Wolfram syndrome 2, a condition marked by insulin-dependent diabetes mellitus, optic atrophy, and other severe manifestations, understanding the role of CDGSH iron-sulfur domain-containing protein 2 could open doors to potential therapeutic strategies for this rare disorder.