Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8N8Q3
UPID:
ENDOV_HUMAN
Alternative names:
Inosine-specific endoribonuclease
Alternative UPACC:
Q8N8Q3; I3L3S4; Q6P2G2; Q86X99; Q8NAK0
Background:
Endonuclease V, known for its unique ability to specifically cleave inosine-containing RNAs, plays a pivotal role in RNA metabolism. This enzyme targets RNA by cleaving at the second phosphodiester bond 3' to inosine, showcasing activity against both single-stranded and double-stranded RNAs. Its preference for single-stranded RNAs highlights its specialized function in processing mRNAs and tRNAs that contain inosine, a modification occurring post-transcriptionally in various RNAs.
Therapeutic significance:
Understanding the role of Endonuclease V could open doors to potential therapeutic strategies. Its involvement in RNA editing and processing mechanisms suggests a broader regulatory role, possibly in antiviral responses or RNA stability, offering a novel target for therapeutic intervention.